In this Cubs at Cardinals prediction, the two NL Central Division rivals will do battle in St. Louis on Wednesday night in game three of this four-game series. The Cubs are still in first place in the NL Central Division but the Brewers and Cardinals have both closed the gap. The pitching matchup in game three of the series will feature Cubs' lefty Matthew Boyd (6-3, 2.84) taking on Cardinals' righty Andre Pallante (5-3, 4.48). The first pitch is scheduled for 7:45 PM EST. Read on for more in th... Read more

The Cubs are facing off against the Cardinals in game three of their series at Busch Stadium in St. Louis, Missouri; keep reading for our Cubs versus Cardinals Prediction. Chicago is at the top of the NL Central with a record of 46-33. St. Louis is second in the NL Central with a record of 44-36. The Cubs were 6-7 versus the Cardinals in 2024. The first pitch is scheduled for 7:45 p.m. EDT. Need some winners this baseball season? Check out our Free MLB Picks. Cubs' Mound Falling ApartThe Cubs gr... Read more

Get our free Baseball betting pick for the St. Louis Cardinals vs Chicago Cubs matchup and gain an edge as a Baseball bettor. Read more

The Chicago Cubs are -135 favorites vs the St. Louis Cardinals Chicago Cubs vs St. Louis Cardinals Over / Under today: 9 Runs Chicago Cubs / St. Louis Cardinals TV Channel: MARQ | FDMW The Chicago Cubs (-135) visit Busch Stadium to take on the St. Louis Cardinals (+110) on Wednesday, June 25, 2025. First pitch is scheduled for 7:45pm EDT in St. Louis, MO, MO. This season, the Chicago Cubs are 46-33 against the spread (ATS), while the St. Louis Cardinals are 45-35 ATS. Chicago Cubs vs St. Louis C... Read more