It’s the middle game of a three-game interleague series on the diamond in the Windy City as the St. Louis Cardinals travel to face the Chicago White Sox Wednesday night and we have you covered with our Cardinals vs. White Sox prediction. St. Louis dropped three of four games over the weekend against Milwaukee as they were downed 3-2 in the series finale Sunday afternoon. Chicago was swept on the road by Texas over the weekend as they were downed 2-1 in the series finale Sunday. This article was... Read more

In the middle game of a three-game interleague series, the St. Louis Cardinals are taking on the Chicago White Sox inside Rate Field on Wednesday night in our Cardinals vs. White Sox prediction. This article was written ahead of the opening game of the series on Tuesday. The Cardinals are fourth in the NL Central with a 37-35 record and are sending veteran right-hander Sonny Gray to the mound. The White Sox are fifth in the AL Central with a 23-49 record and have young righty Sean Burke getting... Read more

Get our free Baseball betting pick for the Chicago White Sox vs St. Louis Cardinals matchup and gain an edge as a Baseball bettor. Read more

The St. Louis Cardinals are -190 favorites vs the Chicago White Sox St. Louis Cardinals vs Chicago White Sox Over / Under today: 8.5 Runs St. Louis Cardinals / Chicago White Sox TV Channel: FDMW | CHSN The St. Louis Cardinals (-190) visit Rate Field to take on the Chicago White Sox (+155) on Wednesday, June 18, 2025. First pitch is scheduled for 7:40pm EDT in Chicago, IL, IL. This season, the St. Louis Cardinals are 38-35 against the spread (ATS), while the Chicago White Sox are 42-31 ATS. St. L... Read more