On Friday, the Chicago White Sox and Chicago Cubs will face off at Wrigley Field, and we have you ready to go with our White Sox vs. Cubs prediction. The Windy City Showdown starts at 2:20 p.m. ET. These Chicago rivals met four times last season. The Cubs swept the 2024 Crosstown Classic series and are 8-2 in their last ten meetings with the White Sox. The over was 6-4 in those ten games. If you want the White Sox vs. Cubs prediction, read on and check out our MLB Predictions to beat the sportsb... Read more

In the opening game of a three-game interleague series, the Chicago White Sox are taking on the Chicago Cubs inside Wrigley Field on Friday afternoon in our White Sox vs. Cubs prediction. The White Sox lost on Thursday on the road to the Cincinnati Reds 7-1 while the Cubs were off on Thursday. The White Sox are fifth in the AL Central with a 14-30 record and are sending rookie right-hander Shane Smith to the mound. The Cubs are first in the NL Central with a 25-19 record and have rookie righty C... Read more

Get our free Baseball betting pick for the Chicago Cubs vs Chicago White Sox matchup and gain an edge as a Baseball bettor. Read more

Chicago Cubs (25-19) vs Chicago White Sox (14-30) Game Info: Friday, May 16, 2025 at 2:20 pm (Wrigley Field) S. Smith (R) vs C. Horton (R) Betting Odds: Chicago Cubs -238 / Chicago White Sox +195 --- Over/Under: 11 Click Here for the Latest Odds Where to Watch: MLB.TV The Chicago White Sox and the Chicago Cubs meet Friday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Chicago Cubs predict... Read more